![]() ![]() Results showed that both doses of ticagrelor reduced the likelihood of cardiovascular death, heart attack or stroke, which was the study’s primary endpoint. The average time since patients had suffered a qualifying heart attack was 1.7 years. The patients’ mean age was 65 years, and 76% were male. “That was the basis for our trial,” he said at the press conference. The question, however, was whether the dose patients needed 2 hours after a heart attack would still be needed 2 years after a heart attack. Sabatine said that the event curves between patients taking the drug with aspirin and those taking aspirin alone continued to widen each month up to the 1 year mark, suggesting that there might be a continued benefit after that point. Ticagrelor is a dual antiplatelet therapy currently prescribed for patients with acute coronary syndrome. Sabatine presented the results in Saturday’s late-breaking session and at a press conference. Sabatine, MD, MPH, chair of the TIMI Study Group and senior physician in the Cardiovascular Division at Brigham and Women’s Hospital and Harvard Medical School, Boston. Efficacy was virtually the same with both doses, according to Marc S. Patients in the trial were randomly assigned a twice-daily regimen of ticagrelor at 90 mg or 60 mg or placebo, in addition to low-dose aspirin. The trial’s full name is Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54. All had experienced a heart attack in the previous 1 to 3 years and had at least 1 other factor, such as diabetes or advanced age, that put them at risk of a second heart attack. The results, simultaneously published in the New England Journal of Medicine, were reported from the PEGASUS-TIMI 54 trial, which involved 21,162 patients at more than 1000 sites in 31 countries. Patients who took ticagrelor with aspirin for an extended period after suffering a heart attack were less likely to die later from cardiovascular causes, heart attack or stroke, according to results presented early Saturday at the 64 th Annual Scientific Session of the American College of Cardiology, being held March 14-16, 2015, in San Diego, California.
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